FRONTENAC, Mo. — Two people died in a wrong-way collision on Interstate 64 Wednesday night, a three-vehicle crash that closed westbound lanes for several hours.

First Alert 4 reported that the crash happened around 9:30 p.m. November 4, east of North Ballas Road. The station cited the Missouri State Highway Patrol’s crash report.

A 25-year-old woman driving the wrong direction in the westbound lanes struck a vehicle driven by a 30-year-old man head-on. A third vehicle then struck the man’s vehicle from behind, according to that account.

Both the woman and the man were pronounced dead at the scene. The third driver was not injured.

The report establishes the wrong-way movement but does not explain how the vehicle entered opposing traffic or establish an underlying cause. No impairment finding is reported here.

The closure affected a major regional route overnight. The reported several-hour shutdown should not be read as a statement that all westbound lanes remain closed this afternoon.